3-Methyl-N-[(phenylMethoxy)carbonyl]-L-valine
CBZ-L-tert-leucine
CAS: 62965-10-0
Molecular Formula: C14H19NO4
3-Methyl-N-[(phenylMethoxy)carbonyl]-L-valine - Names and Identifiers
| Name | CBZ-L-tert-leucine |
| Synonyms | Z-Tle-OH CBZ-L-tert-leucine N-Carbobenzoxy-(S)-tert-leucine Benzyloxycarbonyl-L-tert-leucine N-Benzyloxycarbonyl-tert-leucine N-[(Benzyloxy)carbonyl]-3-methyl-L-valine N-(Benzyloxycarbonyl)-L-tert-butylglycine 3-Methyl-N-[(phenylMethoxy)carbonyl]-L-valine L-valine, 3-methyl-N-[(phenylmethoxy)carbonyl]- 2S-BenzyloxycarbonylaMino-3,3-diMethylbutyric Acid 3,3-dimethyl-2-(phenylmethoxycarbonylamino)butanoic acid (S)-2-(((Benzyloxy)carbonyl)aMino)-3,3-diMethylbutanoic acid |
| CAS | 62965-10-0 |
| InChI | InChI=1/C14H19NO4/c1-14(2,3)11(12(16)17)15-13(18)19-9-10-7-5-4-6-8-10/h4-8,11H,9H2,1-3H3,(H,15,18)(H,16,17)/t11-/m1/s1 |
3-Methyl-N-[(phenylMethoxy)carbonyl]-L-valine - Physico-chemical Properties
| Molecular Formula | C14H19NO4 |
| Molar Mass | 265.3 |
| Density | 1.160±0.06 g/cm3(Predicted) |
| Boling Point | 436.4±38.0 °C(Predicted) |
| Flash Point | 217.708°C |
| Solubility | Chloroform (Sparingly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Oil |
| Color | Pale to Light Yellow Thick |
| pKa | 4.01±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.528 |
| MDL | MFCD00137411 |
3-Methyl-N-[(phenylMethoxy)carbonyl]-L-valine - Risk and Safety
| HS Code | 29225090 |
| Hazard Class | IRRITANT |
3-Methyl-N-[(phenylMethoxy)carbonyl]-L-valine - Introduction
CBZ-L-tert-leucine(CBZ-L-tert-leucine) is an organic compound, which is a protected carbonyl derivative formed by replacing the hydrogen on the α-aminocarbonyl group of leucine with a benzyl group and a carbonyl group.
Nature of CBZ-L-tert-leucine:
-Appearance: Usually a white crystalline solid.
-Solubility: It is soluble in common organic solvents and has low solubility in water.
-Melting point: The melting point is approximately 110-112 degrees Celsius.
Purpose of CBZ-L-tert-leucine:
- CBZ-L-tert-leucine can be used as a protecting group in organic synthesis reactions.
-It can be used to protect the α-aminocarbonyl group of leucine from interference by other reactants during peptide synthesis.
Preparation of CBZ-L-tert-leucine:
The preparation of CBZ-L-tert-leucine is mainly carried out by the following steps:
1. L-tert-leucine reacts with benzyl alcohol to generate L-tert-leucine benzyl ester.
2. Using an appropriate acid catalyst, the L-tert-leucine benzyl ester reacts with carbon dioxide to generate CBZ-L-tert-leucine and benzyl alcohol.
CBZ-L-tert-leucine safety information:
CBZ-L-tert-leucine is not currently recognized as a toxic substance, but as a chemical, it still needs to be used and disposed of properly. When using CBZ-L-tert-leucine for experiments, care should be taken to comply with laboratory safety procedures and take appropriate protective measures, such as wearing gloves and protective glasses.
Nature of CBZ-L-tert-leucine:
-Appearance: Usually a white crystalline solid.
-Solubility: It is soluble in common organic solvents and has low solubility in water.
-Melting point: The melting point is approximately 110-112 degrees Celsius.
Purpose of CBZ-L-tert-leucine:
- CBZ-L-tert-leucine can be used as a protecting group in organic synthesis reactions.
-It can be used to protect the α-aminocarbonyl group of leucine from interference by other reactants during peptide synthesis.
Preparation of CBZ-L-tert-leucine:
The preparation of CBZ-L-tert-leucine is mainly carried out by the following steps:
1. L-tert-leucine reacts with benzyl alcohol to generate L-tert-leucine benzyl ester.
2. Using an appropriate acid catalyst, the L-tert-leucine benzyl ester reacts with carbon dioxide to generate CBZ-L-tert-leucine and benzyl alcohol.
CBZ-L-tert-leucine safety information:
CBZ-L-tert-leucine is not currently recognized as a toxic substance, but as a chemical, it still needs to be used and disposed of properly. When using CBZ-L-tert-leucine for experiments, care should be taken to comply with laboratory safety procedures and take appropriate protective measures, such as wearing gloves and protective glasses.
Last Update：2024-04-09 02:00:47
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